Zimlovisertib
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Zimlovisertib

SKU TQ0167-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 1,533 CAD

Products Details

Product Description

– Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) (IC50s: 0.2 and 2.4 nM in the cell and PBMC assay).

Web ID

– TQ0167

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H20FN3O4

References

– Lee KL, et al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem. 2017 Jul 13;60(13):5521-5542.

CAS Number

– 1817626-54-2

Molecular Weight

– C18H20FN3O4

Compound Purity

– 0.9821

SMILES

– O(C[C@@H]1[C@H](CC)[C@H](F)C(=O)N1)C=2C3=C(C=C(C(N)=O)C(OC)=C3)C=CN2

Pathway

– Immunology/Inflammation|||NF-κB

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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