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LY 3000328
Price range: 155 CAD through 1,680 CAD
Products Details
Product Description
– LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S with IC50 values of 7.7 and 1.67 nM for human and mouse cathepsin S, respectively. LY 3000328 (Cathepsin S inhibitor) may slow or prevent abdominal aortic aneurysm (AAA) expansion and/or reduce the risk of AAA rupture by inhibiting cathepsin S-mediated degradation of extracellular matrix proteins, elastin and collagen.
Web ID
– TQ0116
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C25H29FN4O5
Citations
– 1. Zhang Y, Yang L, Gan Y, et al.Benzydamine attenuates microglia-mediated neuroinflammation and ischemic brain injury by targeting cathepsin s.International Immunopharmacology.2025, 146: 113824.
References
– Jadhav PK, et al. Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm. ACS Med Chem Lett. 2014 Aug 27;5(10):1138-42.
CAS Number
– 1373215-15-6
Molecular Weight
– C25H29FN4O5
Compound Purity
– 0.9954
SMILES
– CNC(=O)O[C@H]1COc2ccc(cc2[C@@H]1NC(=O)c1ccc(F)cc1)N1CCN(CC1)C1COC1
Pathway
– Proteases/Proteasome
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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