SAP15

Name: SAP15 | Research Reagent — Buy Online | Immunomart
Brand: TargetMol
SKU: TP2705-10 mg

SKU TP2705-10 mg Category Peptide Brand: TargetMol

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Products Details

Product Description

– SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic peptide composed of 15 amino acids, derived from human beta-defensin 3, with the ability to penetrate cells and mitigate intracellular inflammation. It achieves its anti-inflammatory effects by blocking the phosphorylation of HDAC5, which in turn reduces NF-κB p65 phosphorylation. In macrophages stimulated with LPS, SAP15 suppresses the phosphorylation of both HDAC5 and NF-κB p65, demonstrating potent anti-inflammatory actions. Furthermore, treatment with SAP15 in LPS-induced chondrocytes elevates aggrecan and type II collagen levels while reducing osteocalcin expression. This peptide is valuable for exploring inflammation regulation and the development of anti-inflammatory therapies in biomaterials.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– TP2705

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C68H131N31O18S3

CAS Number

– 1403753-45-6

Molecular Weight

– C68H131N31O18S3

SMILES

– [C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC(CN)=O)=O)CS)=O)CO)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CS)=O)CS)=O)CCCNC(=N)N)=O)(C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CCCCN)=O)CCCNC(=N)N

Product type

– Peptide

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.