Protosappanin A
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Protosappanin A

SKU TJS1779-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 142 CAD through 1,872 CAD

Products Details

Product Description

– Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.

Web ID

– TJS1779

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C15H12O5

References

– Antimicrobial activity and synergy of antibiotics with two biphenyl compounds, protosappanins A and B from Sappan Lignum against methicillin-resistant Staphylococcus aureus strains. J Pharm Pharmacol. 2015 Oct;67(10):1439-47.

CAS Number

– 102036-28-2

Molecular Weight

– C15H12O5

Compound Purity

– 0.9982

SMILES

– Oc1ccc-2c(OCC(=O)Cc3cc(O)c(O)cc-23)c1

Pathway

– Microbiology/Virology|||Apoptosis|||Angiogenesis|||Chromatin/Epigenetic|||NF-κB|||JAK/STAT signaling|||Stem Cells|||Proteases/Proteasome|||Immunology/Inflammation|||Neuroscience|||Tyrosine Kinase/Adaptors

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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