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NCT-58
Price range: 61 CAD through 1,498 CAD
Products Details
Product Description
– NCT-58 is a potent C-terminal HSP90 inhibitor. NCT-58 does not induce the heat shock response (HSR). NCT-58 elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells.
Web ID
– T9996
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C27H34N2O5
References
– Park S, et al. The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells. Cell Death Discov. 2021;7(1):354.
CAS Number
– 2411429-33-7
Molecular Weight
– C27H34N2O5
Compound Purity
– 0.9875
SMILES
– COc1cc(NC(=O)c2ccc3OC(C)(C)C=Cc3c2OC)ccc1OCCC1CCCCN1
Pathway
– Metabolism|||Cytoskeletal Signaling
Product type
– Small Compound
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