– (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a multifunctional chemical probe featuring an azide group for use in click chemistry. As a building block and template for synthetic targeted protein degradation models, this compound serves as a linker in the E3 enzyme ligand conjugates pivotal for PROTAC research involving the creation of reactive protein degraders, specifically VH032 conjugates. It engages in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups and can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.