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Metformin

SKU T8526-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 62 CAD through 443 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 50 mg 500 mg

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Products Details

Product Description

– Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is commonly used in type 2 diabetes research.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T8526

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C4H11N5

Citations

– 1. Ma W, Wu Q, Wang S, et al.A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke.Journal of Neuroinflammation.2023, 20(1): 1-23. 2. Zhang W, Li X, Jiang M, et al.SOCS3 deficiency-dependent autophagy repression promote the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway.Journal of Leukocyte Biology.2023: qiad020. 3. Fan P, Lu Y, Wei H, et al.Metformin attenuates sevoflurane-induced neurogenesis damage and cognitive impairment: involvement of the Nrf2/G6PD pathway.Metabolic Brain Disease.2023: 1-17. 4. Mlicka A, Mlicki P, Niewiadomski P, et al.Synergistic effect of metformin and doxorubicin on the metastatic potential of T24 cells.Acta Histochemica.2023, 125(1): 151975. 5. Jia Y, Cui R, Wang C, et al. Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway. Redox Biology. 2020: 101534. 6. Zhan Z T, Liu L, Cheng M Z, et al. The Effects of 6 Common Antidiabetic Drugs on Anti-PD1 Immune Checkpoint Inhibitor in Tumor Treatment. Journal of Immunology Research. 2022 7. Chen H, Sa G, He S, et al. In vitro and in vivo synergistic anti-tumor effect of LIN28 inhibitor and metformin in oral squamous cell carcinoma. European Journal of Pharmacology. 2021 Jan 15;891:173757. doi: 10.1016 8. Lan H, Dong Z W, Zhang M Y, et al.Sinapic acid modulates oxidative stress and metabolic disturbances to attenuate ovarian fibrosis in letrozole‐induced polycystic ovary syndrome SD rats.Food Science & Nutrition.2024 9. Wu W, Li J, Yin Y, et al.Rutin attenuates ensartinib-induced hepatotoxicity by non-transcriptional regulation of TXNIP.Cell Biology and Toxicology.2024, 40(1): 38.

References

– Erices R, et al. Metformin, at concentrations corresponding to the treatment of diabetes, potentiates the cytotoxic effects of carboplatin in cultures of ovarian cancer cells. Reprod Sci. 2013 Dec;20(12):1433-46.

CAS Number

– 657-24-9

Molecular Weight

– C4H11N5

Compound Purity

– 0.9977

SMILES

– CN(C)C(=N)NC(N)=N

Pathway

– Autophagy|||Chromatin/Epigenetic|||PI3K/Akt/mTOR signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.