JAK-IN-27
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JAK-IN-27

SKU T79110-5 mg Category Brand:

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Products Details

Product Description

– JAK-IN-27, also known as compound 1, is an orally active, potent inhibitor of the JAKS family kinases, displaying inhibitory concentrations (IC50s) of 3.0 nM for TYK2, 7.7 nM for JAK1, and 629.6 nM for JAK3. Moreover, JAK-IN-27 impedes IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells with an IC50 of 23.7 nM [1].

Web ID

– T79110

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H21F2N7O

CAS Number

– 2673176-36-6

Molecular Weight

– C20H21F2N7O

SMILES

– C(=O)(N1C2CN(C=3C=4N(C=C(N3)C=5C=NN(C)C5)N=CC4)CC1CC2)[C@H]6C(F)(F)C6

Pathway

– Chromatin/Epigenetic|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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