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Products Details
Product Description
– YKL-5-124 TFA, a potent and selective irreversible covalent inhibitor of CDK7, demonstrates IC50 values of 53.5 nM for CDK7 and 9.7 nM for the CDK7/Mat1/CycH complex. It exhibits over 100-fold selectivity for CDK7 over CDK9 and CDK2, while showing no activity against CDK12 and CDK13. This compound effectively induces cell-cycle arrest, inhibits E2F-driven gene expression, and has minimal impact on the phosphorylation status of RNA polymerase II.
Web ID
– T73633
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C30H34F3N7O5
CAS Number
– 2748220-93-9
Molecular Weight
– C30H34F3N7O5
SMILES
– C(C(O)=O)(F)(F)F.N(C(=O)C1=CC=C(NC(C=C)=O)C=C1)C=2C3=C(C(C)(C)N(C(N[C@H](CN(C)C)C4=CC=CC=C4)=O)C3)NN2
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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