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PLX5622

SKU T7100-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 138 CAD through 2,208 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– PLX5622 is a highly selective, brain-penetrant, and orally active CSF1R inhibitor.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T7100

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H19F2N5O

Citations

– 1. Yu Z, Fang X, Liu W, et al. Microglia Regulate Blood–Brain Barrier Integrity via MiR‐126a‐5p/MMP9 Axis during Inflammatory Demyelination. Advanced Science. 2022: 2105442 2. Li C, Wu H, Na H S T, et al. Neuronal-Microglial Liver X receptor β Activating Decrease Neuroinflammation and Chronic Stress-induced Depression-Related Behavior in Mice. Brain Research. 2022: 148112. 3. Huang H Y, Chen Y Z, Zhao C, et al.Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells.Nature Communications.2024, 15(1): 9337.

References

– Rosin JM, Vora SR, Kurrasch DM.Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific effects on mice, including accelerated weight gain, hyperactivity and anxiolytic-like behaviour[J].Brain Behav Immun. 2018 Oct;73:682-697.

CAS Number

– 1303420-67-8

Molecular Weight

– C21H19F2N5O

Compound Purity

– 0.9984

SMILES

– COc1ncc(F)cc1CNc1ccc(Cc2c[nH]c3ncc(C)cc23)c(F)n1

Pathway

– Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.