GLPG1837
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GLPG1837

SKU T7083-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 1,262 CAD

Products Details

Product Description

– GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.

Web ID

– T7083

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C16H20N4O3S

References

– Van der Plas SE, et al. Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent. J Med Chem. 2018 Feb 22;61(4):1425-1435.

CAS Number

– 1654725-02-6

Molecular Weight

– C16H20N4O3S

Compound Purity

– 0.9973

SMILES

– CC1(C)Cc2c(sc(NC(=O)c3cc[nH]n3)c2C(N)=O)C(C)(C)O1

Pathway

– Autophagy|||Membrane transporter/Ion channel

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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