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AS1842856

SKU T6762-5 mg Category Small Compound Brand: TargetMol

Price range: 75 CAD through 952 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– AS1842856 is a Foxo1 inhibitor (IC50=30 nM) that specifically blocks the transcriptional activity of Foxo1 and reduces its activity by directly binding to activated FoxO1. AS1842856 has autophagy inhibitory activity.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6762

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H22FN3O3

Citations

– 1. Lu Y, Huang R, Sun Z, et al.A bovine milk-derived peptide ameliorates pancreatic β-cell dedifferentiation through PI3K/Akt/FOXO1 signaling in type 2 diabetes.Food & Function.2023 2. Chen Q, Gao F, Wu J, et al.Comprehensive pan‐cancer analysis of mitochondrial outer membrane permeabilisation activity reveals positive immunomodulation and assists in identifying potential therapeutic targets for immunotherapy resistance.Clinical and Translational Medicine.2024, 14(6): e1735. 3. Tan Z, Pan K, Sun M, et al.CCKBR+ cancer cells contribute to the intratumor heterogeneity of gastric cancer and confer sensitivity to FOXO inhibition.Cell Death & Differentiation.2024: 1-16.

References

– Takeyuki Nagashima,et al.Mol Pharmacol.2010,78(5):961-970.

CAS Number

– 836620-48-5

Molecular Weight

– C18H22FN3O3

Compound Purity

– 0.9954

SMILES

– CCn1cc(C(O)=O)c(=O)c2c(N)c(F)c(NC3CCCCC3)cc12

Pathway

– Autophagy|||Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.