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EHT 1864 2HCl
Price range: 62 CAD through 1,573 CAD
Products Details
Product Description
– EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3 (Kd=40/50/60/250 nM). EHT 1864 inhibits Rac, Ras, and Tiam-induced growth transformation of NIH-3T3 fibroblasts.
Web ID
– T6483
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C25H29Cl2F3N2O4S
Citations
– 1. Weddle E A, Köseoğlu V K, DeVasure B A, et al. The type three secretion system effector protein IpgB1 promotes Shigella flexneri cell-to-cell spread through double-membrane vacuole escape. PLoS Pathogens. 2022, 18(2): e1010380
2. Liu X, Wang S, Zheng H, et al. Epimedokoreanin C, A Prenylated Flavonoid Isolated from Epimedium Koreanum, Induces Non-Apoptotic Cell Death with the Characteristics of Methuosis in Lung Cancer Cells. American Journal of Cancer Research. 2021, 11(7): 3496.
3. Liu Y, Sun Y, Xu Y, et al.Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells.Cell Chemical Biology.2023
4. Zhao P, Zhang J, Song W, et al.Incarvine C and its analogues inhibit the formation of cell cytoskeleton by targeting Rac1.Bioorganic Chemistry.2024: 107512.
References
– Shutes A, et al. J Biol Chem. 2007, 282(49), 35666-35678.
CAS Number
– 754240-09-0
Molecular Weight
– C25H29Cl2F3N2O4S
Compound Purity
– 0.9918
SMILES
– Cl.Cl.FC(F)(F)c1ccc2c(SCCCCCOc3coc(CN4CCOCC4)cc3=O)ccnc2c1
Pathway
– MAPK|||Cell Cycle/Checkpoint|||GPCR/G Protein
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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