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AMG 517

SKU T6379-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 75 CAD through 890 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV1.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6379

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H13F3N4O2S

Citations

– 1. Pan X, Li R, Guo H, et al. Dihydropyridine Calcium Channel Blockers Suppress the Transcription of PD-L1 by Inhibiting the Activation of STAT1. Frontiers in Pharmacology. 2021 Jan 13;11:539261. doi: 10.3389/fphar.2020.539261. eCollection 2020. 2. Zhang M, Jia X, Cheng C, et al.Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection.Acta Pharmacologica Sinica.2023: 1-12.

References

– Gavva NR, et al. J Pharmacol Exp Ther, 2007, 323(1), 128-137.

CAS Number

– 659730-32-2

Molecular Weight

– C20H13F3N4O2S

Compound Purity

– 0.9966

SMILES

– O(C1=C2C(SC(NC(C)=O)=N2)=CC=C1)C=3C=C(N=CN3)C4=CC=C(C(F)(F)F)C=C4

Pathway

– Membrane transporter/Ion channel

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.