Download Files:

KU-57788

SKU T6276-2 mg Category Small Compound Brand: TargetMol

Price range: 54 CAD through 1,566 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 10 mg 100 mg 25 mg 5 mg 50 mg 500 mg

Clear

Products Details

Product Description

– NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6276

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C25H19NO3S

Citations

– 1. Zhang B, Wu H, Hao J, et al. Inhibition of DNA-PKcs activity re-sensitizes uveal melanoma cells to radio-and chemotherapy. Biochemical and Biophysical Research Communications. 2019 2. Feng Y L, Liu S C, Chen R D, et al.Proximal binding of dCas9 at a DNA double strand break stimulates homology-directed repair as a local inhibitor of classical non-homologous end joining.Nucleic Acids Research.2023: gkad116.

References

– Sunada S, et al. Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair. Cancer Sci. 2016 Sep;107(9):1250-5.

CAS Number

– 503468-95-9

Molecular Weight

– C25H19NO3S

Compound Purity

– 1

SMILES

– O=c1cc(oc2c(cccc12)-c1cccc2c3ccccc3sc12)N1CCOCC1

Pathway

– PI3K/Akt/mTOR signaling|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.