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Fosbretabulin Disodium
Price range: 51 CAD through 590 CAD
Products Details
Product Description
– Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibits the polymerization of tubulin (IC50: 2.4 μM), and also disrupts tumor vasculature.
Web ID
– T6272
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C18H19O8P·2Na
Citations
– 1. Han T, Duan Q, Yang R, et al. Monitoring the therapeutic efficacy of CA4P in the rabbit VX2 liver tumor using dynamic contrast-enhanced MRI. Diagnostic and Interventional Radiology. 2021, 27(5): 587.
2. Meng F, Zou B, Yang R, et al. The diagnostic efficiency of the perfusion-related parameters in assessing the vascular disrupting agent (CA4P) response in a rabbit VX2 liver tumor model. Acta Radiologica. 2021: 02841851211032450.
References
– Woods JA, et al. Br J Cancer 1995, 71(4), 705-711.
CAS Number
– 168555-66-6
Molecular Weight
– C18H19O8P·2Na
Compound Purity
– 0.9996
SMILES
– [Na+].[Na+].COc1ccc(C=C/c2cc(OC)c(OC)c(OC)c2)cc1OP([O-])([O-])=O
Pathway
– Cytoskeletal Signaling|||Apoptosis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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