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Tubastatin A Hydrochloride

SKU T6161-5 mg Category Small Compound Brand: TargetMol

Price range: 72 CAD through 331 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Tubastatin A Hydrochloride (TSA HCl) is an effective and specific HDAC6 inhibitor (IC50: 15 nM). It has selectivity (>1000-fold) against all other isozymes except HDAC8 (>57-fold).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6161

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H21N3O2·HCl

Citations

– 1. Liu S, Zhang H L, Li J, et al.Tubastatin A potently inhibits GPX4 activity to potentiate cancer radiotherapy through boosting ferroptosis.Redox Biology.2023: 102677. 2. Jia S, Wen X, Zhu M, et al.The pluripotent-to-totipotent state transition in mESCs activates the intrinsic apoptotic pathway through DUX-induced DNA replication stress.Cellular and Molecular Life Sciences.2024, 81(1): 1-12.

References

– Butler KV, et al, J Am Chem Soc, 2010, 132(31), 10842-10846.

CAS Number

– 1310693-92-5

Molecular Weight

– C20H21N3O2·HCl

Compound Purity

– 0.9925

SMILES

– Cl.CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO

Pathway

– DNA Damage/DNA Repair|||Apoptosis|||Chromatin/Epigenetic|||Autophagy

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.