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IU1

SKU T6107-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 86 CAD through 717 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6107

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H21FN2O

Citations

– 1. Wu W, Xu H, Liao C, et al. Blockade of USP14 potentiates type I interferon signaling and radiation-induced antitumor immunity via preventing IRF3 deubiquitination. Cellular Oncology. 2022: 1-15 2. Yue X, Liu T, Wang X, et al.Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy.Acta Pharmaceutica Sinica B.2023

References

– Byung-Hoon L, et al. Nature, 2010, 467(7312), 179-184.

CAS Number

– 314245-33-5

Molecular Weight

– C18H21FN2O

Compound Purity

– 0.993

SMILES

– Cc1c(ccn1-c1ccc(F)cc1)C(=O)CN1CCCC1

Pathway

– DNA Damage/DNA Repair|||Autophagy|||Ubiquitination|||Cell Cycle/Checkpoint

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.