H-151
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H-151

SKU T5674-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 1,579 CAD

Products Details

Product Description

– H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammatory diseases in vivo and ex vivo.

Web ID

– T5674

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H17N3O

Citations

– 1. Song P, Yang W, Lou K F, et al. UNC13D inhibits STING signaling by attenuating its oligomerization on the endoplasmic reticulum. EMBO reports. 2022: e55099 2. Chen Q, Tang L, Zhang Y, et al. STING up-regulates VEGF expression in oxidative stress-induced senescence of retinal pigment epithelium via NF-κB/HIF-1α pathway. Life Sciences. 2022: 120089. 3. Qiao W, Hu C, Ma J, et al.Low-dose metronomic chemotherapy triggers oxidized mtDNA sensing inside tumor cells to potentiate CD8+ T anti-tumor immunity.Cancer Letters.2023: 216370. 4. Li J, Sun Y, Zhao X, et al.Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.Cell Death & Disease.2023, 14(4): 1-16. 5. Qiao W, Chen J, Zhou H, et al.A Single‐Atom Manganese Nanozyme Mn‐N/C Promotes Anti‐Tumor Immune Response via Eliciting Type I Interferon Signaling.Advanced Science.2024: 2305979. 6. Wang Z, Zhang X, Luo Y, et al.Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis).Cell Death & Disease.2024, 15(5): 375. 7. Fan X, Peng Y, Li B, et al.Liver‐Secreted Extracellular Vesicles Promote Cirrhosis‐Associated Skeletal Muscle Injury Through mtDNA‐cGAS/STING Axis.Advanced Science.2025: 2410439. 8. STING agonist-based ER-targeting molecules boost antigen cross-presentation

References

– Kobritz M, et al. H151, A SMALL MOLECULE INHIBITOR OF STING AS A NOVEL THERAPEUTIC IN INTESTINAL ISCHEMIA-REPERFUSION INJURY. Shock. 2022 Sep 1;58(3):241-250.

CAS Number

– 941987-60-6

Molecular Weight

– C17H17N3O

Compound Purity

– 0.9997

SMILES

– CCc1ccc(NC(=O)Nc2c[nH]c3ccccc23)cc1

Pathway

– Immunology/Inflammation

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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