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TBHQ

SKU T5364-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 66 CAD through 77 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 g 1 mL * 10 mM (in DMSO)500 mg

Clear

Products Details

Product Description

– TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T5364

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C10H14O2

Citations

– 1. Zhu X, Huang N, Ji Y, et al.Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway.Biomedicine & Pharmacotherapy.2023, 167: 115567. 2. Yu D, Cai W, Shen T, et al.PM2. 5 exposure increases dry eye disease risks through corneal epithelial inflammation and mitochondrial dysfunctions.Cell Biology and Toxicology.2023: 1-16. 3. An Y, Li H, Wang M, et al. Nuclear factor erythroid 2-related factor 2 agonist protects retinal ganglion cells in glutamate excitotoxicity retinas. Biomedicine & Pharmacotherapy. 2022, 153: 113378 4. Yang Q, Cai W, Jin H, et al. Downregulation of Inflammatory Response via Nrf2/Trx1/TXNIP Axis in Oxidative Stress-Induced ARPE-19 Cells and Mouse Model of AMD. Oxidative Medicine and Cellular Longevity. 2022 5. Chen Y, Shi J, Wang X, et al.An antioxidant feedforward cycle coordinated by linker histone variant H1. 2 and NRF2 that drives nonsmall cell lung cancer progression.Proceedings of the National Academy of Sciences.2023, 120(39): e2306288120. 6. Wang M, Hu S, Yang J, et al.Arenobufagin inhibits lung metastasis of colorectal cancer by targeting c-MYC/Nrf2 axis.Phytomedicine.2024: 155391. 7. Ma F, Yao J, Niu X, et al.MARK4 promotes the malignant phenotype of gastric cancer through the MAPK/ERK signaling pathway.Pathology-Research and Practice.2024: 155471.

References

– Imhoff BR, et al. Tert-butylhydroquinone induces mitochondrial oxidative stress causing Nrf2 activation. Cell Biol Toxicol. 2010 Dec;26(6):541-51.

CAS Number

– 1948-33-0

Molecular Weight

– C10H14O2

Compound Purity

– 0.9917

SMILES

– C(C)(C)(C)C1=C(O)C=CC(O)=C1

Pathway

– Autophagy|||Immunology/Inflammation|||Apoptosis|||MAPK

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.