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C-176

SKU T5154-5 mg Category Small Compound Brand: TargetMol

Price range: 48 CAD through 824 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– C-176 (STING inhibitor 1) is a STING inhibitor with selectivity and blood-brain barrier permeability. C-176 inhibits STING-mediated IFNβ production and possesses anti-inflammatory activity.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T5154

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C11H7IN2O4

Citations

– 1. Liu X, Cen X, Wu R, et al.ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade.Nature Communications.2023, 14(1): 4066. 2. Jin L, Yu B, Wang H, et al.STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury.Free Radical Biology and Medicine.2023 3. Li R, Xiong Y, Ma L, et al.Neutrophil extracellular traps promote macrophage inflammation in psoriasis.Clinical Immunology.2024: 110308.

References

– Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.

CAS Number

– 314054-00-7

Molecular Weight

– C11H7IN2O4

Compound Purity

– 0.9882

SMILES

– [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(I)cc1

Pathway

– Immunology/Inflammation

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.