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GSK4112

SKU T5045-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 48 CAD through 734 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 50 mg

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Products Details

Product Description

– GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 of 0.4 μM and serves as a small molecule chemical probe for studying the cell biology of the nuclear heme receptor Rev-erbα.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T5045

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H21ClN2O4S

Citations

– 1. Xu L, yi Zhou W, Xu T, et al. Rev-erbα Mediates Steatosis in Alcoholic Fatty Liver Through Regulating Autophagy. Cell & Bioscience. 2021 Jul 10;11(1):129. doi: 10.1186/s13578-021-00622-4. 2. Liu Q, Xu L, Wu M, et al. Rev-erbα exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy. Cell & Bioscience. 2021, 11(1): 1-15.

References

– Grant D, et al. GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. ACS Chem Biol. 2010 Oct 15;5(10):925-932.

CAS Number

– 1216744-19-2

Molecular Weight

– C18H21ClN2O4S

Compound Purity

– 0.9963

SMILES

– CC(C)(C)OC(=O)CN(Cc1ccc(s1)[N+]([O-])=O)Cc1ccc(Cl)cc1

Pathway

– Autophagy

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.