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2-Aminoethyl diphenylborinate

SKU T4693-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 46 CAD through 510 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 50 mg 500 mg

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Products Details

Product Description

– 2-Aminoethyl diphenylborinate (2-APB) is a chemical compound that inhibits IP3 receptors and TRP channels, though it activates TRPV1, TRPV2, and TRPV3 at higher concentrations.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T4693

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C14H16BNO

Citations

– 1. Zheng Q, Zou Y, Teng P, et al. Mechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2/4 Expression via CaMKII/MEKK3/ERK5 Axis in Endothelial Cells. Cells. 2022, 11(14): 2191 2. Zhan C S, Chen J, Chen J, et al. CaMK4‐dependent phosphorylation of Akt/mTOR underlies Th17 excessive activation in experimental autoimmune prostatitis. The FASEB Journal. 2020, 34(10): 14006-14023 3. Zhang Z, Zhou H, Gu W, et al.CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes.Nature Chemical Biology.2024: 1-11. 4. Gan P, Wu H, Zhu Y, et al.A new look at angiogenesis inhibition of geniposide in experimental arthritis by blocking angiopoietin‐2 exocytosis.Phytotherapy Research.2024 5. Zhong T, Chen S, Deng K, et al.Magnesium alleviates extracellular histone-induced apoptosis and defective bacterial phagocytosis in macrophages by regulating intracellular calcium signal.International Immunopharmacology.2024, 132: 111870. 6. Qu Y, Wang S, Jiang H, et al.The Ca2+-dependent phosphatase calcineurin dephosphorylates TBK1 to suppress antiviral innate immunity.Journal of Virology.2024: e00016-24. 7. Qu Y, Wang S, Jiang H, et al.Newcastle disease virus infection induces parthanatos in tumor cells via calcium waves.PLoS pathogens.2024, 20(12): e1012737.

References

– Bai et al (2006) Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB). J.Pharmacol.Exp.Ther. 319 1452

CAS Number

– 524-95-8

Molecular Weight

– C14H16BNO

Compound Purity

– 0.9874

SMILES

– NCCOB(c1ccccc1)c1ccccc1

Pathway

– Metabolism|||Membrane transporter/Ion channel

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.