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Ro5-3335

SKU T4687-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 67 CAD through 954 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T4687

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C13H10ClN3O

Citations

– 1. Lin W, Wan X, Sun A, et al. RUNX1/EGFR Pathway Contributes to STAT3 Activation and Tumor Growth Caused by Hyperactivated mTORC1. Molecular Therapy-Oncolytics. 2021 2. Wang Y, Wang Q, Wang B, et al. Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells. Cell death & disease. 2020, 11(11): 1-13. 3. Wu Y, Hu S S, Zhang R, et al.Single cell RNA sequencing unravels mechanisms underlying senescence-like phenotypes of Alveolar Macrophages.iScience.2023 4. Cui X, Huo D, Wang Q, et al.RUNX1/NPM1/H3K4me3 complex contributes to extracellular matrix remodeling via enhancing FOSL2 transcriptional activation in glioblastoma.Cell Death & Disease.2024, 15(1): 98.

References

– Cunningham L, et al.Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7.

CAS Number

– 30195-30-3

Molecular Weight

– C13H10ClN3O

Compound Purity

– 0.9995

SMILES

– Clc1ccc2NC(=O)CN=C(c3ccc[nH]3)c2c1

Pathway

– Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.