Download Files:
GSK-25
Price range: 62 CAD through 765 CAD
Products Details
Product Description
– GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
Web ID
– T4488
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C24H16Cl2F2N6O
Citations
– 1. Yuan Y, Xu J, Jiang L, et al. Discovery, Optimization, and Structure–Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma. Journal of Medicinal Chemistry. 2021
References
– Sehon CA, et al. Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases [J]. J Med Chem. 2008 Nov 13;51(21):6631-4.
CAS Number
– 874119-56-9
Molecular Weight
– C24H16Cl2F2N6O
Compound Purity
– 0.9859
SMILES
– CC1=C(C(N=C(N1)c1ccnc(Cl)c1)c1ccc(Cl)cc1F)C(=O)Nc1cc2cn[nH]c2cc1F
Pathway
– PI3K/Akt/mTOR signaling|||MAPK|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
