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Tucidinostat

SKU T4481-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 93 CAD through 1,480 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and shows no effect on HDAC4/5/6/7/9.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T4481

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H19FN4O2

Citations

– 1. Zha J, Zhong M, Pan G, et al.Stratification and therapeutic potential of ELL in cytogenetic normal acute myeloid leukemia.Gene.2022: 147110. 2. Shao J, Ye Z, Shen Z, et al.Chidamide improves gefitinib treatment outcomes in NSCLC by attenuating recruitment and immunosuppressive function of myeloid-derived suppressor cells.Biomedicine & Pharmacotherapy.2024, 173: 116306.

References

– Zhong M, et al. Preclinical Evaluation of the HDAC Inhibitor Chidamide in Transformed Follicular Lymphoma. Front Oncol. 2021 Dec 3;11:780118.

CAS Number

– 1616493-44-7

Molecular Weight

– C22H19FN4O2

Compound Purity

– 0.9876

SMILES

– Nc1cc(F)ccc1NC(=O)c1ccc(CNC(=O)C=Cc2cccnc2)cc1

Pathway

– Chromatin/Epigenetic|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.