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RO1138452
Price range: 70 CAD through 1,363 CAD
Products Details
Product Description
– RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1].
Web ID
– T4436
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C19H23N3O
References
– Clark R D, Jahangir A, Severance D, et al. Discovery and SAR development of 2-(phenylamino) imidazolines as postacyclin receptor antagonists[J]. Bioorganic & medicinal chemistry letters, 2004, 14(4): 1053-1056.
CAS Number
– 221529-58-4
Molecular Weight
– C19H23N3O
Compound Purity
– 0.9934
SMILES
– CC(C)Oc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1
Pathway
– GPCR/G Protein|||Immunology/Inflammation
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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