AD80
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AD80

SKU T4301-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 62 CAD through 2,368 CAD

Products Details

Product Description

– AD80, a multikinase inhibitor, targets RET, RAF, SRC, and S6K with significantly reduced activity on mTOR.

Web ID

– T4301

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H19F4N7O

Citations

– 1. de Almeida L C, Carlos J A E G, Rezende-Teixeira P, et al. AD80, a multikinase inhibitor, as a potential drug candidate for colorectal cancer therapy. Life Sciences. 2022: 120911. 2. Carlos J A E G, Lima K, Costa-Lotufo L V, et al. AD80, a multikinase inhibitor, exhibits antineoplastic effects in acute leukemia cellular models targeting the PI3K/STMN1 axis. Investigational New Drugs. 2021 Aug;39(4):1139-1149. doi: 10.1007/s10637-021-01066-w. Epub 2021 Jan 21. 3. Carlos J A E G, Lima K, Costa-Lotufo L V, et al. AD80, a multikinase inhibitor, exhibits antineoplastic effects in acute leukemia cellular models targeting the PI3K/STMN1 axis. Investigational New Drugs. 2021 Aug;39(4):1139-1149. doi: 10.1007/s10637-021-01066-w. Epub 2021 Jan 21. 4. Lima K, de Miranda L B L, Del Milagro Bernabe Garnique A, et al.The Multikinase Inhibitor AD80 Induces Mitotic Catastrophe and Autophagy in Pancreatic Cancer Cells.Cancers.2023, 15(15): 3866.

References

– Dar AC, et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.Nature. 2012 Jun 6;486(7401):80-4.

CAS Number

– 1384071-99-1

Molecular Weight

– C22H19F4N7O

Compound Purity

– 0.999

SMILES

– CC(C)n1nc(-c2ccc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)cc2)c2c(N)ncnc12

Pathway

– Apoptosis|||PI3K/Akt/mTOR signaling|||Angiogenesis|||MAPK|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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