Diffractaic Acid

SKU T4114-1 mg Category Natural Product Brand: TargetMol

Price range: 157 CAD through 2,384 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Diffractaic Acid (NSC 685595) can inhibit LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells with activity value of 8 μM.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T4114

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H22O7

Citations

– 1. Kalın Ş N, Altay A, Budak H. Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells. Chemico-Biological Interactions. 2022: 109984 2. Günaydın Ş, Sulukoğlu E K, Kalın Ş N, et al.Diffractaic acid exhibits thioredoxin reductase 1 inhibition in lung cancer A549 cells.Journal of Applied Toxicology.2023;1–10. 3. Budak B, Kalın Ş N, Yapça Ö E.Antiproliferative, antimigratory, and apoptotic effects of diffractaic and vulpinic acids as thioredoxin reductase 1 inhibitors on cervical cancer.Naunyn-Schmiedeberg’s Archives of Pharmacology.2023: 1-11. 4. Sulukoğlu E K, Günaydın Ş, Kalın Ş N, et al.Diffractaic acid exerts anti-cancer effects on hepatocellular carcinoma HepG2 cells by inducing apoptosis and suppressing migration through targeting thioredoxin reductase 1.Naunyn-Schmiedeberg’s Archives of Pharmacology.2024: 1-11.

References

– Kumar KC, et al. Lichen metabolites. 1. Inhibitory action against leukotriene B4 biosynthesis by a non-redox mechanism. J Nat Prod. 1999 Jun;62(6):817-20.

CAS Number

– 436-32-8

Molecular Weight

– C20H22O7

Compound Purity

– 0.9987

SMILES

– COc1cc(C)c(C(=O)Oc2cc(C)c(C(O)=O)c(O)c2C)c(OC)c1C

Pathway

– Apoptosis|||Immunology/Inflammation

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.