AG126
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AG126

SKU T4092-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 64 CAD through 714 CAD

Products Details

Product Description

– AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 μM) and platelet-derived GFRK (IC50 > 100 μM).

Web ID

– T4092

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C10H5N3O3

References

– Novogrodsky, A.,Vanichkin, A.,Patya, M., et al. Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 264(5163), 1319-1322 (1994).

CAS Number

– 118409-62-4

Molecular Weight

– C10H5N3O3

Compound Purity

– 0.9872

SMILES

– Oc1cc(C=C(C#N)C#N)ccc1[N+]([O-])=O

Pathway

– Neuroscience|||Immunology/Inflammation|||MAPK

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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