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Products Details
Product Description
– Phenoxybenzamine is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine also shows antitumor activity[1][2].
Web ID
– HY-B0431
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C18H22ClNO
References
– [1]Habbe N, et al. Urapidil in the preoperative treatment of pheochromocytomas: a safe and cost-effective method. World J Surg. 2013 May;37(5):1141-6.|[2]Lin XB, et al. Anti-tumor activity of phenoxybenzamine hydrochloride on malignant glioma cells. Tumour Biol. 2016 Mar;37(3):2901-8.|[3]Rau TF, et al. Phenoxybenzamine is neuroprotective in a rat model of severe traumatic brain injury. Int J Mol Sci. 2014 Jan 20;15(1):1402-17.
CAS Number
– 59-96-1
Molecular Weight
– 303.83
SMILES
– CC(N(CCCl)CC1=CC=CC=C1)COC2=CC=CC=C2
Clinical Information
– Launched
Research Area
– Cancer; Endocrinology; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Adrenergic Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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