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HG-7-85-01

SKU T38653-1 mg Category Small Compound Brand: TargetMol

Price range: 117 CAD through 1,744 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFRα, Kit, and Src kinases, with inhibitory effects on the proliferation of a variety of cancer cell lines, leading to G0/G1-phase blockade and apoptosis induction in BCR-ABL-expressing cells.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T38653

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C31H31F3N6O2S

References

– Ellen Weisberg, et al. Discovery of a Small-Molecule Type II Inhibitor of Wild-Type and Gatekeeper Mutants of BCR-ABL, PDGFRalpha, Kit, and Src Kinases: Novel Type II Inhibitor of Gatekeeper Mutants. Blood. 2010 May 27;115(21):4206-16.

CAS Number

– 1258391-13-7

Molecular Weight

– C31H31F3N6O2S

Compound Purity

– 0.9808

SMILES

– O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(CC)CC2)C3=CC=CC(=C3)C4=NC=5SC(=NC5C=C4)NC(=O)C6CC6

Pathway

– Cytoskeletal Signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.