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Nexinhib20

SKU T38384-1 mg Category Small Compound Brand: TargetMol

Price range: 67 CAD through 261 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Nexinhib20 is an inhibitor of exosome synthesis and transport with anti-inflammatory activity, inhibits RAB27A and neutral sphingomyelinase 2 (nSMase2) nsMase2, inhibits IL-8-induced β(2) integrin-dependent adhesion of human neutrophils in the subfluidic phase, and inhibits neutrophil adhesion and β(2) integrin activation through antagonism of the rac-1-guanosine 5′-triphosphate interaction. beta(2) integrin activation.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T38384

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C15H16N4O3

References

– Johnson, J.L., Ramadass, M., He, J., et al. Identification of neutrophil exocytosis inhibitors (nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: Druggability of the small GTPase Rab27a. J. Biol. Chem. 291(50), 25965-25982 (2016).

CAS Number

– 331949-35-0

Molecular Weight

– C15H16N4O3

Compound Purity

– 0.9989

SMILES

– O=C(C(C)(C)C)C(N1N=CN=C1)=CC2=CC=CC([N+]([O-])=O)=C2

Pathway

– Immunology/Inflammation|||GPCR/G Protein|||MAPK

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.