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Liothyronine
$60 – $144
Products Details
Product Description
– Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].
Web ID
– HY-A0070A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H12I3NO4
Citations
– Adipocyte. 2022 Dec;11(1):84-98.|Cell Death Discov. 2022 Apr 30;8(1):236.|Cell Metab. 2023 Sep 7;S1550-4131(23)00304-2.|Food Science and Human Wellness. 2023 Nov;12(6);2061-2072.|J Med Chem. 2022 Jan 21.|J Nutr Biochem. 2020 Apr;78:108335.|Methods Mol Biol. 2023;2683:103-111.|Nat Commun. 2023 Jun 2;14(1):3208.|Patent. US20220389379A1.|J Ethnopharmacol. 2022 Aug 11;115622.|JCI Insight. 2021 Jun 22;6(12):142838.
References
– [1]Lin KH, et al. Stimulation of proliferation by 3,3′,5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.|[2]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3′,5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.|[3]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34.
CAS Number
– 6893-02-3
Molecular Weight
– 650.97
Compound Purity
– 99.82
SMILES
– OC1=C(I)C=C(OC2=C(I)C=C(C[C@H](N)C(O)=O)C=C2I)C=C1
Clinical Information
– Launched
Research Area
– Cancer; Endocrinology
Solubility
– 1M NaOH : 50 mg/mL (ultrasonic;warming;heat to 60°C)|DMSO : 50 mg/mL (ultrasonic)
Target
– Endogenous Metabolite;Thyroid Hormone Receptor
Isoform
– Human Endogenous Metabolite
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
