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Pifithrin-β hydrobromide

SKU T3637-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 54 CAD through 531 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T3637

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C16H17BrN2S

Citations

– 1. Xu D, Xu Y, Cui Q, et al. Cold atmospheric plasma as a potential tool for multiple myeloma treatment. Oncotarget. 2018, 9(26): 18002 2. Feng F, Wang Z, Li R, et al. Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2. Biomedicine & Pharmacotherapy. 2019 Apr;112:108669 3. Zhang H, Zhang L, Wu Z.Interaction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development.Cell Division.2025, 20(1): 1-14. 4. Jiang Z, Sun X, Li Y, et al.Anlotinib induced ferroptosis through the p53/xCT/GPX4 pathway in non-small cell lung cancer.Translational Oncology.2025, 53: 102289.

References

– Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57.

CAS Number

– 511296-88-1

Molecular Weight

– C16H17BrN2S

Compound Purity

– 0.9974

SMILES

– Br.Cc1ccc(cc1)-c1cn2c3CCCCc3sc2n1

Target

– Estrogen Receptor/ERR

Pathway

– Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.