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XL413
Price range: 77 CAD through 1,109 CAD
Products Details
Product Description
– XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells.
Web ID
– T3352
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C14H12ClN3O2
Citations
– 1. Yu Z, Deng P, Chen Y, et al. Inhibition of the PLK1‐Coupled Cell Cycle Machinery Overcomes Resistance to Oxaliplatin in Colorectal Cancer. Advanced Science. 2021: 2100759.
2. Liu S, Deng P, Yu Z, et al.CDC7 Inhibition Potentiates Antitumor Efficacy of PARP Inhibitor in Advanced Ovarian Cancer.Advanced Science.2024: 2403782.
References
– Koltun ES, et al. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31.
CAS Number
– 1169558-38-6
Molecular Weight
– C14H12ClN3O2
Compound Purity
– 0.9938
SMILES
– O=C1C2=C(C=3C(O2)=CC=C(Cl)C3)NC(=N1)[C@@H]4CCCN4
Pathway
– Cell Cycle/Checkpoint|||Metabolism|||JAK/STAT signaling|||GPCR/G Protein|||Chromatin/Epigenetic|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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