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GSK-J4
Price range: 82 CAD through 1,179 CAD
Products Details
Product Description
– GSK-J4 (GSK J4 HCl) is a cell permeable prodrug of GSK-J1, a dual inhibitor of the H3K27me3/me2 demethylases JMJD3/KDM6B and UTX/KDM6A (IC50=8.6/6.6 μM). GSK-J4 induces endoplasmic reticulum stress-related apoptosis.
Web ID
– T3100
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C24H27N5O2
Citations
– 1. Zheng B, Liu J, Gao A, et al. Epigenetic reprogramming of H3K27me3 and DNA methylation during leaf-to-callus transition in peach. Horticulture Research. 2022
2. Lin B, Lu B, Hsieh I, et al. Synergy of GSK-J4 With Doxorubicin in KRAS-Mutant Anaplastic Thyroid Cancer. Frontiers in Pharmacology. 2020, 11
References
– Kruidenier L, et al. Nature, 2012, 488(7411), 404-408.
CAS Number
– 1373423-53-0
Molecular Weight
– C24H27N5O2
Compound Purity
– 0.9824
SMILES
– CCOC(=O)CCNc1cc(nc(n1)-c1ccccn1)N1CCc2ccccc2CC1
Pathway
– Apoptosis|||Chromatin/Epigenetic
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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