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Nigericin sodium salt

SKU T3092-1 mg Category Natural Product Brand: TargetMol

Price range: 50 CAD through 1,390 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Nigericin sodium salt is an antibiotic, an NLRP3 activator, and a cationic ion carrier. Nigericin sodium triggers the activation of the NALP3 inflammasome, which inhibits Golgi function and suppresses the growth of Gram-positive bacteria.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T3092

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C40H67NaO11

Citations

– 1. Ju X, Zhu Y, Wang Y, et al. A novel cell culture system modeling the SARS-CoV-2 life cycle. PLoS pathogens. 2021, 17(3): e1009439. 2. Luo R, Hu Y, Wang L, et al.Penthorum chinense Pursh extract ameliorates hepatic steatosis by suppressing pyroptosis via the NLRP3/Caspase‐1/GSDMD pathway.Food Science & Nutrition.2024 3. Li X, Li X, Xiang C, et al.Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis.Cell Reports.2024, 43(9). 4. Song J Q, Shen L J, Wang H J, et al.Discovery of Balasubramide Derivative with Tissue‐Specific Anti‐Inflammatory Activity Against Acute Lung Injury by Targeting VDAC1.Advanced Science.2024: 2410550.

References

– Wu L, et al. Nigericin Boosts Anti-Tumor Immune Response via Inducing Pyroptosis in Triple-Negative Breast Cancer. Cancers (Basel). 2023 Jun 16;15(12):3221.

CAS Number

– 28643-80-3

Molecular Weight

– C40H67NaO11

Compound Purity

– 0.9831

SMILES

– [Na+].[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]1(C)CC[C@@]([H])(O1)[C@]1(C)C[C@@H](C)[C@]2(O1)O[C@]([H])(C[C@@]1([H])CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@@H](OC)[C@H]2C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C

Pathway

– Microbiology/Virology|||Immunology/Inflammation|||NF-κB|||Membrane transporter/Ion channel

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.