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AZD-1480
Price range: 83 CAD through 229 CAD
Products Details
Product Description
– AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies, Post-Polycythaemia Vera, Primary Myelofibrosis (PMF), and Essential Thrombocythaemia Myelofibrosis.
Web ID
– T3069
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C14H14ClFN8
Citations
– 1. Yang T, Shi X, Kang Y, et al. Novel compounds TAD-1822-7-F2 and F5 inhibited HeLa cells growth through the JAK/Stat signaling pathway. Biochemical & Pharmacology. 2018, 103: 118-126
2. Hu Z, Sui Q, Jin X, et al.IL6-STAT3-C/EBPβ-IL6 positive feedback loop in tumor-associated macrophages promotes the EMT and metastasis of lung adenocarcinoma.Journal of Experimental & Clinical Cancer Research.2024, 43(1): 63.
References
– E Derenzini, et al. Blood Cancer J, 2011, 1(12), e46.
CAS Number
– 935666-88-9
Molecular Weight
– C14H14ClFN8
Compound Purity
– 0.9825
SMILES
– C[C@H](Nc1ncc(Cl)c(Nc2cc(C)[nH]n2)n1)c1ncc(F)cn1
Pathway
– Angiogenesis|||Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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