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Oridonin

SKU T2790-1 mL * 10 mM (in DMSO) Category Natural Product Brand: TargetMol

Price range: 72 CAD through 230 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 50 mg

Clear

Products Details

Product Description

– Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2790

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H28O6

Citations

– 1. Li L, Song J, Zhang M, et al. Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy. Acta Pharmacologica Sinica. 2022: 1-15. 2. An Y, Zhu J, Wang X, et al. Oridonin Delays Aging Through the AKT Signaling Pathway. Frontiers in Pharmacology. 2022: 1823 3. Li L, Cheng S Q, Guo W, et al. Oridonin prevents oxidative stress‐induced endothelial injury via promoting Nrf‐2 pathway in ischaemic stroke. Journal of Cellular and Molecular Medicine. 2021 4. Yan H, Zhang R, Yan G, et al.Validation of baicalein and oridonin as nonspecific SARS‐CoV‐2 main protease inhibitors.Phytotherapy Research.2023

References

– Ikezoe T, et al. Int J Oncol, 2003, 23(4), 1187-1193.

CAS Number

– 28957-04-2

Molecular Weight

– C20H28O6

Compound Purity

– 0.9904

SMILES

– CC1(C)CCC(O)C23COC(O)(C(O)C12)C12C(O)C(CCC31)C(=C)C2=O

Pathway

– Cytoskeletal Signaling|||Microbiology/Virology|||PI3K/Akt/mTOR signaling

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.