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JAK3i

SKU T27650-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 560 CAD through 3,168 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– JAK3i is a selective covalent inhibitor of JAK3 kinase. JAK3i reveals two distinct temporal waves of STAT5 phosphorylation and more potently targets the second wave, which is required for cell cycle progression and T cell proliferation.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T27650

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H15FN4O3

References

– Dammeijer F, et al. Low-Dose JAK3 Inhibition Improves Antitumor T-Cell Immunity and Immunotherapy Efficacy. Mol Cancer Ther. 2022;21(9):1393-1405.

CAS Number

– 1918238-72-8

Molecular Weight

– C18H15FN4O3

Compound Purity

– 0.9981

SMILES

– C(OCC)(=O)C=1C2=C(N=CN=C2NC1)C3=CC(NC(C=C)=O)=CC=C3F

Pathway

– Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.