JNK-IN-8
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JNK-IN-8

SKU T2668-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 62 CAD through 1,218 CAD

Products Details

Product Description

– JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM) with over 10-fold selectivity compared to MNK2 and Fms, and no inhibition of Met, c-Kit, or PDGFRβ in the A375 cell line.

Web ID

– T2668

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C29H29N7O2

Citations

– 1. Zhou S, Niu R, Sun H, et al. The MAP3K1/c-JUN signaling axis regulates glioblastoma stem cell invasion and tumor progression. Biochemical and Biophysical Research Communications. 2022, 612: 188-195. 2. Zheng M, Zhai Y, Yu Y, et al.TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response.Cell Metabolism.2024 3. Xie S, Liu H, Zhu S, et al.Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα–JNK pathway.Cancer Gene Therapy.2024: 1-12.

References

– Zhang T, et al. Chem Biol, 2012, 19(1), 140-154.

CAS Number

– 1410880-22-6

Molecular Weight

– C29H29N7O2

Compound Purity

– 0.9959

SMILES

– CN(C)CC=CC(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1

Pathway

– MAPK|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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