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GSK2606414
Price range: 98 CAD through 558 CAD
Products Details
Product Description
– GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase(PERK)inhibitor with IC50 of 0.4 nM. GSK2606414 inhibits PERK activation in cells and suppresses the growth of human tumor xenografts in mice.
Web ID
– T2614
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C24H20F3N5O
Citations
– 1. Guo T, Liu C, Yang C, et al. Immunoproteasome subunit PSMB8 regulates microglia-mediated neuroinflammation upon manganese exposure by PERK signaling. Food and Chemical Toxicology. 2022: 112951.
2. Yuan J, Yao C, Tang J, et al. Enhanced GRP78 protein expression via the IRE1α/ASK1/p38 MAPK pathway during As2O3-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021, 462: 152962.
3. Meng C, Zhang J, Dang B, et al. PERK pathway activation promotes intracerebral hemorrhage induced secondary brain injury by inducing neuronal apoptosis both in vivo and in vitro. Frontiers in Neuroscience. 2018 Feb 28;12:111
4. Kong F, Zou H, Liu X, et al. miR-7112-3p targets PERK to regulate the endoplasmic reticulum stress pathway and apoptosis induced by photodynamic therapy in colorectal cancer CX-1 cells. Photodiagnosis and Photodynamic Therapy. 2020: 101663
5. Liu X, Jin J, Wu Y, et al.Fluoroindole chalcone analogues targeting the colchicine binding site of tubulin for colorectal oncotherapy.European Journal of Medicinal Chemistry.2023: 115540.
References
– Axten JM, et al. J Med Chem. 2012, 55(16), 7193-7207.
CAS Number
– 1337531-36-8
Molecular Weight
– C24H20F3N5O
Compound Purity
– 0.9863
SMILES
– NC1=C2C(=CN(C)C2=NC=N1)C=3C=C4C(=CC3)N(C(CC5=CC(C(F)(F)F)=CC=C5)=O)CC4
Pathway
– Apoptosis|||Autophagy
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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