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GSK2606414

SKU T2614-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 98 CAD through 558 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mL * 10 mM (in DMSO)10 mg 5 mg 50 mg

Clear

Products Details

Product Description

– GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase(PERK)inhibitor with IC50 of 0.4 nM. GSK2606414 inhibits PERK activation in cells and suppresses the growth of human tumor xenografts in mice.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2614

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C24H20F3N5O

Citations

– 1. Guo T, Liu C, Yang C, et al. Immunoproteasome subunit PSMB8 regulates microglia-mediated neuroinflammation upon manganese exposure by PERK signaling. Food and Chemical Toxicology. 2022: 112951. 2. Yuan J, Yao C, Tang J, et al. Enhanced GRP78 protein expression via the IRE1α/ASK1/p38 MAPK pathway during As2O3-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021, 462: 152962. 3. Meng C, Zhang J, Dang B, et al. PERK pathway activation promotes intracerebral hemorrhage induced secondary brain injury by inducing neuronal apoptosis both in vivo and in vitro. Frontiers in Neuroscience. 2018 Feb 28;12:111 4. Kong F, Zou H, Liu X, et al. miR-7112-3p targets PERK to regulate the endoplasmic reticulum stress pathway and apoptosis induced by photodynamic therapy in colorectal cancer CX-1 cells. Photodiagnosis and Photodynamic Therapy. 2020: 101663 5. Liu X, Jin J, Wu Y, et al.Fluoroindole chalcone analogues targeting the colchicine binding site of tubulin for colorectal oncotherapy.European Journal of Medicinal Chemistry.2023: 115540.

References

– Axten JM, et al. J Med Chem. 2012, 55(16), 7193-7207.

CAS Number

– 1337531-36-8

Molecular Weight

– C24H20F3N5O

Compound Purity

– 0.9863

SMILES

– NC1=C2C(=CN(C)C2=NC=N1)C=3C=C4C(=CC3)N(C(CC5=CC(C(F)(F)F)=CC=C5)=O)CC4

Pathway

– Apoptosis|||Autophagy

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.