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(Z)-Semaxinib

SKU T2496-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 83 CAD through 1,595 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– (Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for FGFR, InsR, and EGFR. (Z)-Semaxinib is a quinolone derivative with potential antineoplastic activity.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2496

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C15H14N2O

Citations

– 1. Ma W, Qiu Z, Bai Z, et al. Inhibition of MicroRNA-30a Alleviates Vascular Remodeling in Pulmonary Arterial Hypertension Molecular Therapy-Nucleic Acids. Molecular Therapy-Nucleic Acids. 2. Dai, Yong, et al. Long-Term Effect of a Vaccine Targeting Endothelin-1 Receptor Type A in Pulmonary Arterial Hypertension. Frontiers in Cardiovascular Medicine. 8 (2021): 570

References

– Fong TA, et al. Cancer Res, 1999, 59(1), 99-106.

CAS Number

– 194413-58-6

Molecular Weight

– C15H14N2O

Compound Purity

– 0.9994

SMILES

– C(=C1/C=2C(NC1=O)=CC=CC2)C=3NC(C)=CC3C

Pathway

– Angiogenesis|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.