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GW8510

SKU T24125-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 70 CAD through 1,968 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– GW8510 is a CDK2 (cell cycle protein-dependent kinase 2) inhibitor and RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 improves cognition and prolongs lifespan, which may be related to the modulation of the expression of cell cycle-related protein p21 and CDK family genes, as well as the improvement of mitochondrial function.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T24125

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H15N5O3S2

References

– Chen P, Wu JN, Shu Y, Jiang HG, Zhao XH, Qian H, Chen K, Lan T, Chen CG, Li J. Gemcitabine resistance mediated by ribonucleotide reductase M2 in lung squamous cell carcinoma is reversed by GW8510 through autophagy induction. Clin Sci (Lond). 2018 May 31. pii: CS20180010. doi: 10.1042/CS20180010. [Epub ahead of print] PubMed PMID: 29853661.

CAS Number

– 222036-17-1

Molecular Weight

– C21H15N5O3S2

Compound Purity

– 0.9932

SMILES

– O=C1NC=2C=CC=3N=CSC3C2C1=CNC4=CC=C(C=C4)S(=O)(=O)NC5=NC=CC=C5

Pathway

– Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.