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ABC1183

SKU T23601-5 mg Category Small Compound Brand: TargetMol

Price range: 56 CAD through 93 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen synthetase, β-catenin phosphorylation and MCL1 expression,and is orally active.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T23601

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H14N4OS

References

– Schrecengost RS, et al. In Vitro and In Vivo Antitumor and Anti-Inflammatory Capabilities of the Novel GSK3 and CDK9 Inhibitor ABC1183. J Pharmacol Exp Ther. 2018 Apr;365(1):107-116.

CAS Number

– 1042735-18-1

Molecular Weight

– C18H14N4OS

Compound Purity

– 0.9853

SMILES

– Cc1ccc(Nc2nc(N)c(s2)C(=O)c2ccc(cc2)C#N)cc1

Pathway

– Cell Cycle/Checkpoint|||Stem Cells|||PI3K/Akt/mTOR signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.