(S)-Afatinib
Add to CompareAdded to Compare

Download Files:

(S)-Afatinib

SKU T2303-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 46 CAD through 94 CAD

Products Details

Product Description

– (S)-Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, EGFR (L858R), EGFR (L858R/T790M), HER2, and HER4, respectively.

Web ID

– T2303

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C24H25ClFN5O3

Citations

– 1. Luo P, Yan H, Du J, et al. PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1). Autophagy. 2021 Oct;17(10):3221-3237. 2. Lu H H, Lin S Y, Roc Weng R, et al. Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma. EBioMedicine. 2020, 57: 102846 3. Shang J, Ning S, Chen Y, et al. MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer. Acta Pharmacologica Sinica. 2021, 42(1): 120-131 4. Luo P, Hong H, Zhang B, et al.ERBB4 selectively amplifies TGF-β pro-metastatic responses.Cell Reports.2025, 44(2).

References

– Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11.

CAS Number

– 439081-18-2

Molecular Weight

– C24H25ClFN5O3

Compound Purity

– 0.9996

SMILES

– CN(C)CC=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1

Pathway

– JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
Mexenone
Mexenone Price range: 48 CAD through 157 CAD
1 mL * 10 mM (in DMSO)100 mg200 mg

1000 in stock

Select options
6-Mercaptopurine
6-Mercaptopurine Price range: 50 CAD through 190 CAD
1 g1 mL * 10 mM (in DMSO)25 mg

1000 in stock

Select options
Aspirin
Aspirin Price range: 50 CAD through 139 CAD
1 g1 mL * 10 mM (in DMSO)5 g

1000 in stock

Select options
2,2'-Bipyridine
2,2′-Bipyridine Price range: 46 CAD through 171 CAD
1 g100 mg500 mg

1000 in stock

Select options
7-Chloro-4-(piperazin-1-yl)quinoline
7-Chloro-4-(piperazin-1-yl)quinoline Price range: 56 CAD through 77 CAD
100 mg200 mg

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });