Download Files:
Products Details
Product Description
– IGF-1R inhibitor-2 (example 121) is an insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Downregulation of IGF-1R can reverse the transformed phenotype of tumor cells and potentially render them susceptible to apoptosis[1].
Web ID
– HY-145110
Shipping
– Room temperature
Molecular Formula
– C24H24FN7O2
References
– [1]Stanley Dawes Chamberlain, et al. IR receptor tyrosine kinase and ALK kinase for treating cancer. WO2009020990 A1.
CAS Number
– 1116236-15-7
Molecular Weight
– 461.49
SMILES
– O=C(C1=C(NC2=C3C=CNC3=NC(NC4=C(OC)C=C(CCN(C5)C)C5=C4)=N2)C=CC=C1F)N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– IGF-1R
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
