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Puromycin dihydrochloride
Price range: 62 CAD through 315 CAD
Products Details
Product Description
– Puromycin dihydrochloride (CL13900 dihydrochloride) is a cinnamamide adenosine antibiotic and an inhibitor of protein synthesis. Puromycin dihydrochloride inhibits protein synthesis by binding to RNA and has antitumor and antitrypanosomal activity.
Web ID
– T2219
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H31Cl2N7O5
Citations
– 1. Wang Y N, Ruan D Y, Wang Z X, et al. Targeting the cholesterol-RORα/γ axis inhibits colorectal cancer progression through degrading c-myc. Oncogene. 2022: 1-13.
2. Gao C, Wang H, Wang T, et al. Platelet CLEC‐2 regulates neuroinflammation and restores blood brain barrier integrity in a mouse model of traumatic brain injury. Journal of Neurochemistry. 2020: e14983
3. Han W, Zhang C, Shi C, et al. Roles of eIF3m in the tumorigenesis of triple negative breast cancer. Cancer Cell International. 2020, 20(1): 1-16
4. Han W, Cao F, Gao X J, et al. ZIC1 acts a tumor suppressor in breast cancer by targeting survivin. International Journal of Oncology. 2018 Sep;53(3):937-948
5. Liu S, Zhang X, Yao X, et al.Mammalian IRE1α dynamically and functionally coalesces with stress granules.Nature Cell Biology.2024: 1-15.
6. Li M, Lou L, Ren L, et al.EIF4G2 Promotes Hepatocellular Carcinoma Progression via IRES-dependent PLEKHA1 Translation Regulation.Journal of Proteome Research.2024
References
– Chan C, et al. Incompatibility of chemical protein synthesis inhibitors with accurate measurement of extended protein degradation rates. Pharmacol Res Perspect. 2017 Oct;5(5):e00359.
CAS Number
– 58-58-2
Molecular Weight
– C22H31Cl2N7O5
Compound Purity
– 0.9989
SMILES
– Cl.Cl.COc1ccc(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)n2cnc3c(ncnc23)N(C)C)cc1
Target
– Others
Pathway
– Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Microbiology/Virology
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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