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Quercetin
Price range: 67 CAD through 126 CAD
Products Details
Product Description
– Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90.
Web ID
– T2174
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C15H10O7
Citations
– 1. Guo C R, Zhang Z Z, Zhou X, et al.Chronic cough relief by allosteric modulation of P2X3 without taste disturbance.Nature Communications.2023, 14(1): 5844.
2. Zhang Z, Shi J, Wu Q, et al.JUN mediates Glucocorticoid Resistance by stabilizing HIF1a in T-Cell Acute Lymphoblastic Leukemia.iScience.2023
3. Shan H, Zhang X, Mi Y, et al.Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K/AKT Pathway.Pharmaceuticals.2022, 15(12): 1477.
4. Gul H, Ali R, Rauf M, et al.Aspergillus welwitschiae BK Isolate Ameliorates the Physicochemical Characteristics and Mineral Profile of Maize under Salt Stress.Plants.2023, 12(8): 1703.
5. Li S, Hao L, Hu X, et al.A systematic study on the treatment of hepatitis B-related hepatocellular carcinoma with drugs based on bioinformatics and key target reverse network pharmacology and experimental verification.Infectious Agents and Cancer.2023, 18(1): 41.
6. Qadir M, Hussain A, Hamayun M, et al. Phytohormones Producing Acinetobacter bouvetii P1 Mitigates Chromate Stress in Sunflower by Provoking Host Antioxidant Response. Antioxidants. 2021, 10(12): 1868.
7. Peng D, Chen L, Sun Y, et al. Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling. Biomedicine & Pharmacotherapy. 2020, 125: 109984
8. Shan H, Zhang X, Mi Y, et al.Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K/AKT Pathway.Pharmaceuticals.2022, 15(12): 1477.
9. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet. Planta Medica. 2019, 85(14/15): 1128-1135
10. Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin. Biochemical and Biophysical Research Communications. 2020
References
– Srivastava S, et al. Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis. Sci Rep. 2016 Apr 12;6:24049.
CAS Number
– 117-39-5
Molecular Weight
– C15H10O7
Compound Purity
– 0.9805
SMILES
– Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Pathway
– Autophagy|||Apoptosis|||Immunology/Inflammation|||Metabolism|||NF-κB|||PI3K/Akt/mTOR signaling
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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